Search results for "Cyclin-Dependent Kinase Inhibitor p19"

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Regulation of the p19(Arf)/p53 pathway by histone acetylation underlies neural stem cell behavior in senescence-prone SAMP8 mice.

2015

Brain aging is associated with increased neurodegeneration and reduced neurogenesis. B1/neural stem cells (B1-NSCs) of the mouse subependymal zone (SEZ) support the ongoing production of olfactory bulb interneurons, but their neurogenic potential is progressively reduced as mice age. Although age-related changes in B1-NSCs may result from increased expression of tumor suppressor proteins, accumulation of DNA damage, metabolic alterations, and microenvironmental or systemic changes, the ultimate causes remain unclear. Senescence-accelerated-prone mice (SAMP8) relative to senescence-accelerated-resistant mice (SAMR1) exhibit signs of hastened senescence and can be used as a model for the stud…

SenescenceMaleAgingHistonesMiceNeural Stem CellsNeurospheremedicineSubependymal zoneAnimalsstem cell nicheCyclin-Dependent Kinase Inhibitor p19Mice KnockoutNeuronsbiologyNeurodegenerationNeurogenesishistone acetyltransferasesBrainAcetylationCell BiologyOriginal Articlesmedicine.diseaseGenes p53Neural stem cellChromatinCell biologyadult neurogenesisOxidative StressHistoneImmunologybiology.proteinProtein Processing Post-TranslationalSAMP8 micehistone deacetylasesAging cell

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